Chong Guo

The paper identifies that Purkinje cells selectively inhibit mGluR1-expressing unipolar brush cells through GABAAR and GABABR-mediated pathways, with distinct functional roles in cerebellar circuitry.

The paper shows that metabotropic signaling in neurons exhibits graded heterogeneity, leading to a continuum of temporal response profiles.

The paper shows that climbing fiber synapses inhibit neighboring Purkinje cells via ephaptic coupling, suppressing simple spikes and influencing cerebellar output.

This study creates a transcriptomic atlas of the mouse cerebellum, identifying regional specializations and novel cell types, including two distinct molecular layer interneuron subtypes.