Wade G. Regehr

Specialized outputs and behavioral contributions of Purkinje cell subtypes

The paper identifies molecularly distinct Purkinje cell subtypes and shows they regulate specific behaviors through targeted silencing experiments.

Purkinje cell collaterals preferentially target a subtype of molecular layer interneuron

The paper investigates Purkinje cell connectivity to molecular layer interneuron subtypes and finds that PCs preferentially synapse onto MLI2s and disinhibit MLI1s, revealing feedback pathways that modulate PC firing.

Structural and functional evidence for ephaptic control of Purkinje cell spike timing by networks of molecular layer interneurons

The paper demonstrates that networks of molecular layer interneurons use ephaptic signals to control Purkinje cell firing timing in vivo.

Climbing fibers selectively recruit disinhibitory interneurons to enhance dendritic calcium signaling in cerebellar Purkinje cells

The paper investigates how climbing fiber inputs selectively excite disinhibitory interneurons to enhance dendritic calcium signaling in Purkinje cells, supporting cerebellar learning.

Characterization of direct Purkinje cell outputs to the brainstem

This study characterizes Purkinje cell projections to the brainstem, revealing widespread synapses with regional differences and functional selectivity.

Realistic mossy fiber input patterns to unipolar brush cells evoke a continuum of temporal responses comprised of components mediated by different glutamate receptors

The paper investigates how different glutamate receptor types in unipolar brush cells transform mossy fiber input patterns into diverse temporal responses.

Processing reliant on granule cells is essential for motor learning but dispensable for many cerebellar-dependent behaviors

The paper shows that granule cell signaling is essential for motor learning but not for many cerebellar-dependent behaviors, while Purkinje cell signaling affects both motor learning and other behaviors.

Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs

The paper shows that variable synaptic weights from Purkinje cells to cerebellar nuclei neurons affect both firing rate and timing, suggesting a dual coding mechanism.

A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain

The paper identifies a Purkinje cell to parabrachial nucleus pathway that enables cerebellar influence over forebrain regions involved in nonmotor functions, distinct from the traditional deep cerebellar nuclei pathway.

Cerebellar circuits for disinhibition and synchronous inhibition

The paper identifies two MLI subtypes with distinct connectivity and functional roles in cerebellar circuits, showing how disinhibition gates cerebellar-dependent learning.

Structured connectivity in the cerebellum enables noise-resilient pattern separation

The paper maps cerebellar connectivity in mice and shows how structured, non-random motifs improve pattern separation while maintaining encoding capacity.

Unusually slow spike frequency adaptation in deep cerebellar nuclei neurons preserves linear transformations on the sub-second time scale

The paper investigates spike-frequency adaptation in deep cerebellar nuclei neurons and finds it is unusually slow, allowing linear firing responses on sub-second time scales.

Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex

The paper identifies that Purkinje cells selectively inhibit mGluR1-expressing unipolar brush cells through GABAAR and GABABR-mediated pathways, with distinct functional roles in cerebellar circuitry.

Short-term plasticity persists in the absence of PKC phosphorylation of Munc18-1

This study shows that post-tetanic potentiation (PTP) persists in mice with Munc18-1 unable to be phosphorylated by PKC, indicating PTP mechanisms are independent of this phosphorylation.

Candelabrum cells are molecularly distinct, ubiquitous interneurons of the cerebellar cortex with specialized circuit properties

The paper identifies candelabrum cells as abundant, GABAergic interneurons in the cerebellar cortex with distinct molecular properties and a unique role in circuit function.

Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses

The paper shows that metabotropic signaling in neurons exhibits graded heterogeneity, leading to a continuum of temporal response profiles.

Synaptic inputs to the inferior olive from cerebellar and vestibular nuclei have distinct release kinetics and neurotransmitters

Climbing fiber synapses rapidly inhibit neighboring Purkinje cells via ephaptic coupling

The paper shows that climbing fiber synapses inhibit neighboring Purkinje cells via ephaptic coupling, suppressing simple spikes and influencing cerebellar output.

Cerebellar Purkinje cell activity modulates aggressive behavior

This study shows that modulating cerebellar Purkinje cell activity in mice affects aggressive behavior without altering motor function.

A transcriptomic atlas of the mouse cerebellum reveals regional specializations and novel cell types

This study creates a transcriptomic atlas of the mouse cerebellum, identifying regional specializations and novel cell types, including two distinct molecular layer interneuron subtypes.

Cerebellum-specific deletion of the GABAA receptor δ subunit alters anxiety-like, social and maternal behaviors without affecting motor performance

This study deletes the GABAA receptor δ subunit in cerebellar granule cells in mice, revealing its role in anxiety, social, and maternal behaviors without affecting motor performance.