Diwakar Suresh

Targeting AATF reprograms the tumor microenvironment and suppresses hepatocellular carcinoma via MIR100HG TGFβ signaling

This study shows that silencing AATF in the tumor microenvironment suppresses hepatocellular carcinoma growth by disrupting TGFβ signaling through the MIR100HG lncRNA.

Hepatic loss of AATF attenuates MASH by suppressing AKT/mTORC1 signaling and reprogramming lipid metabolism

This study shows that loss of AATF reduces MASH in mice by suppressing AKT/mTORC1 signaling and altering lipid metabolism.

Green Jackfruit Flour Prevents Metabolic Dysfunction-Associated Steatohepatitis and Progression to Hepatocellular Carcinoma via the AMPK and MAPK Signaling Pathways

This study shows that green jackfruit flour reduces MASH and HCC in mice by activating AMPK and inhibiting MAPK pathways through microbial fermentation products.