Author

Manju Moorthy

Primary ORCID profile (0009-0002-5282-9147 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Manju MoorthyiD1 paper

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Akshatha N. SrinivasiD· 2 shared Divya P. KumariD· 2 shared Diwakar SureshiD· 2 shared Gopalkrishna Ramaswamy· 2 shared Prasanna K. SanthekaduriD· 2 shared Amith Bharadwaj S. A.· 1 shared Archana P Thankamony· 1 shared Bharathwaaj Gunaseelan· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Akshatha N. SrinivasORCID

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3 papers

Recent·Most cited

Targeting AATF reprograms the tumor microenvironment and suppresses hepatocellular carcinoma via MIR100HG TGFβ signaling

Diwakar Suresh, Akshatha N. Srinivas, Bharathwaaj Gunaseelan, Amith Bharadwaj S. A., Manju Moorthy, Gopalkrishna Ramaswamy, Suchitha Satish, Prashant M. Vishwanath, Prasanna K. Santhekadur, Saravana Babu Chidambaram, Divya P. Kumar

This study shows that silencing AATF in the tumor microenvironment suppresses hepatocellular carcinoma growth by disrupting TGFβ signaling through the MIR100HG lncRNA.

Molecular Therapy Oncology · Jun 6, 2026Peer-reviewedCancer Biology

Hepatic loss of AATF attenuates MASH by suppressing AKT/mTORC1 signaling and reprogramming lipid metabolism

Akshatha N. Srinivas, Diwakar Suresh, Prajna Anirvan, Manju Moorthy, Gopalkrishna Ramaswamy, Suma Maduvanahalli Nataraj, Prasanna K. Santhekadur, Deepak Suvarna, Shivaram P. Singh, Divya P. Kumar

This study shows that loss of AATF reduces MASH in mice by suppressing AKT/mTORC1 signaling and altering lipid metabolism.

Molecular Medicine · Jan 13, 2026Peer-reviewedMolecular Biology

Repurposing statins in combination therapy for effective ablation of metastatic breast cancer

Rifat Aara, Neeha Sinai Borker, Jyothilakshmi Sajimon, Seemadri Subhadarshini, VP Snijesh, Vidya P Nimbalkar, Manju Moorthy, Archana P Thankamony, R Athul Krishnan, Diya Aich, Debolina Das, Mohit Kumar Jolly, Jyothi S. Prabhu, Radhika Nair

This study evaluates lovastatin's efficacy in combination with chemotherapy to ablate chemoresistant metastatic breast cancer cells by targeting Macc1 overexpression.

Advances in Cancer Biology - Metastasis · Nov 27, 2025Peer-reviewedCancer Biology