NeurosciencebioRxivPreprint
Deciphering the mechanistic basis for the pathological effect of the Gαo E246K mutation in neurodevelopmental disorder
Isra Sadiya, Irina Nekrasova, Meirav Avital‐Shacham…·Mickey Kosloff
The paper investigates the molecular mechanism of the Gαo E246K mutation in neurodevelopmental disorders, showing it disrupts the GTPase cycle by impairing Gβγ dissociation, leading to dominant-negative effects.
DOI 10.1101/2025.09.03.673757