Author

Isra Sadiya

University of HaifaORCID 0009-0009-0567-8594Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Mickey KosloffiD· 2 shared Andreea NissenkorniD· 1 shared David Peter SiderovskiiD· 1 shared Dina Schneidman‐DuhovnyiD· 1 shared Dustin E. BoschiD· 1 shared Ehud BanneiD· 1 shared Irina NekrasovaiD· 1 shared Keren ZohariD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Mickey KosloffORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 3, 2025

Deciphering the mechanistic basis for the pathological effect of the Gαo E246K mutation in neurodevelopmental disorder

Isra Sadiya, Irina Nekrasova, Meirav Avital‐Shacham…·Mickey Kosloff

The paper investigates the molecular mechanism of the Gαo E246K mutation in neurodevelopmental disorders, showing it disrupts the GTPase cycle by impairing Gβγ dissociation, leading to dominant-negative effects.

DOI 10.1101/2025.09.03.673757

humanproteomics

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Pharmacology & ToxicologyJournal of Biological ChemistryPeer-reviewedAug 22, 2025

Developing inhibitors of the guanosine triphosphate hydrolysis accelerating activity of Regulator of G protein Signaling-14

Percy S. Agogo-Mawuli, Isra Sadiya, Tigran M. Abramyan…·David Peter Siderovski

This paper identifies and validates non-covalent inhibitors of RGS14 GAP activity using structure-guided virtual screening and machine learning, showing improved potency and CNS penetration.

2 citations

protein structuredeep learning

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