Treating the untreatable: Reversing β-lactam resistance in MRSA by membrane-domain-dissolving antibiotics
Adéla Melcrová, Willem Woudstra, Michaela Wenzel, Mariella Gabler, Wenche Stensen, John S. M. Svendsen, Wouter H. Roos, Romana Schirhagl
This paper demonstrates that membrane-domain-dissolving antibiotics can reverse β-lactam resistance in MRSA by dissolving membrane domains, as shown through multiple experimental methods.
bioRxiv · Oct 27, 2025 · PreprintBiophysics