Wouter H. Roos

The paper shows that lipid asymmetry drives pore formation in membranes, which function as self-resealing scramblases to restore balance.

This study shows dimeric Alix nucleates CHMP4 polymerization, essential for ESCRT-III membrane remodeling, and demonstrates that dimerization is required for plasma membrane repair.

This paper proposes a multi-scale model of the pyruvate dehydrogenase complex (PDHc) revealing a nested shell structure that coordinates enzyme communication during pyruvate oxidation.

This study examines how modifications to HIV envelope proteins affect the mechanical properties of virus-like particles, finding that certain modifications increase stiffness and breaking force.

This paper demonstrates that membrane-domain-dissolving antibiotics can reverse β-lactam resistance in MRSA by dissolving membrane domains, as shown through multiple experimental methods.

This study investigates how supported lipid bilayers interact with their substrate, revealing pinning, stretching, pore formation, and shape changes with biophysical implications.

This study uses high-speed atomic force microscopy to directly observe secondary nucleation in huntingtin amyloid formation, revealing dynamic processes and the role of flanking segments.

This study demonstrates that cationic liposomes can fuse with membranes to deliver cargo efficiently but temporarily alter membrane properties.

This study investigates how glycan-induced structural activation of the HPV capsid facilitates entry by reducing intercapsomere flexibility.

This study shows MDA5 compacts dsRNA via ATP-dependent loop extrusion, stabilizing the structure through CARD domain oligomerization.