Qing Chen

SpacerScope provides a high-speed, high-sensitivity off-target profiling tool for RNA-guided nucleases, accurately recovering all validated off-target sites and detecting complex indel-containing sites.

This study identifies a hypermorphic mutation in TaARF4-A2 that represses SPL-mediated developmental timing, leading to altered wheat architecture by promoting aerial branching and reducing reproductive development.

This study compares temporal transcriptomic changes in iPSC-derived motor neurons with SOD1 mutations D91A and G94A to understand their impact on ALS severity.

The paper identifies a mutation in the Q gene that leads to increased spike density and improved processing quality in wheat by overexpressing Qc1.