Dajiang Qin

This study shows that the Par complex regulates cell polarity and differentiation by modulating FAK signaling through the AKT-FURIN-LEFTY pathway in mouse embryonic stem cells.

This study reveals how the Rpd3L complex uses an asymmetric architecture to activate deacetylation in response to chromatin context.

This study creates a single-cell RNA sequencing atlas of mouse nasal development, identifying cell clusters and subtypes, and revealing regulators of lineage specification.

This study resolves the structural mechanism of ncBAF-nucleosome interaction, showing BCL7B's role in chromatin remodeling and its connection to nuclear actin networks.

This study compares temporal transcriptomic changes in iPSC-derived motor neurons with SOD1 mutations D91A and G94A to understand their impact on ALS severity.

This study shows that calorie restriction exacerbates neuronal degeneration in mtDNA-depleted neurons by increasing ER-mitochondria calcium transfer, suggesting CR may not be beneficial for mitochondrial epilepsy.

The paper constructs a multimodal brain cell atlas of adult macaques across their lifespan, revealing aging-related molecular changes and identifying aging hotspots and regulatory loci.

This study identifies a previously unrecognized CSF drainage pathway through blood vessels in the nasal mucosa, showing that CSF tracers can be drained via both lymphatic and venous routes in mice.