Bill Ling

A modular method for rapidly prototyping targeted gas vesicle protein nanoparticles

The paper describes a modular method to create targeted gas vesicle protein nanoparticles using His-tagged antibody fragments and Ni-NTA functionalization, validated for PSMA targeting.

Harmonic imaging for nonlinear detection of acoustic biomolecules

This study introduces harmonic xAM (HxAM) imaging to improve GV detection sensitivity and imaging depth in vivo.

Truly tiny acoustic biomolecules for ultrasound imaging and therapy

This paper introduces bicones, tiny acoustic contrast agents based on gas vesicles, showing their effectiveness in imaging and therapy through ultrasound.

Gas vesicle-blood interactions enhance ultrasound imaging contrast

This study investigates how gas vesicles interact with blood components and shows that surface modifications can alter these interactions to improve in vivo performance.

Acoustic biomolecules enhance hemodynamic functional ultrasound imaging of neural activity

This paper introduces gas vesicles as ultrasound contrast agents to enhance transcranial hemodynamic functional ultrasound imaging of mouse brain activity.