Mikhail G. Shapiro

This paper introduces cell chirp ultrasound to image single cells in opaque tissues, showing it can track rare cell populations over time with high specificity and sensitivity.

The paper quantifies magnetofluorescence of MagLOV in mammalian cells and neurons, showing magnetic field effects across cell types.

This paper introduces an ultrasonic reporter of kinase activity (UReKA) to monitor PKA activity in opaque tissues by altering ultrasound scattering of gas vesicles.

The paper develops a synthetic paracrine signaling system using auxin to enable spatially restricted multicellular responses in mouse xenografts.

This study demonstrates that functional ultrasound imaging can reliably map motor effector encoding in the human sensorimotor cortex at submillimeter resolution, enabling single-trial decoding of movement-related activity.

This paper introduces a method to modulate protein function through genetically encoded oxidative chemistry by using photosensitizers to generate reactive oxygen species and control protein activity.

This paper introduces a 3D ultrasound imaging method called Takoyaki to visualize contrast agents and reporter genes in living organisms, demonstrating its use in in vitro and in vivo settings.

This study improves BURST imaging by using statistical metrics to reduce background noise and enhance detection reliability in molecular imaging.

The paper describes a modular method to create targeted gas vesicle protein nanoparticles using His-tagged antibody fragments and Ni-NTA functionalization, validated for PSMA targeting.

This paper develops two novel acoustic reporter genes enabling two-color ultrasound imaging of gene expression in bacteria and mice.

This study develops a multimodal ultrasound imaging platform to track tumor-brain interactions in glioblastoma models over time, revealing spatial displacement of brain regions and vascular remodeling.

This paper introduces sono-uncaging, a method using ultrasound to control chemical reactivity in opaque materials, demonstrating spatial patterning with a diagnostic imaging transducer.

This paper develops probiotic biosensors that use ultrasound to noninvasively image gut inflammation in mice, improving diagnosis of IBD.

This paper introduces HAM-SVD, a method for ultrafast ultrasound imaging of gas vesicles that improves signal-to-background ratio compared to existing techniques.

This paper develops a system to image in situ transcriptional activity in opaque tissues using ultrasound and acoustic reporter genes, demonstrating long-term tracking of gene expression in the mouse brain.

This paper introduces a new ultrasound beamforming algorithm that improves image contrast and resolution while maintaining computational efficiency.

This paper designs a thermal bioswitch to control macrophage activation in vivo, enabling spatially localized gene expression for at least 14 days after ultrasound heating.

This paper introduces a drug delivery system using ultrasound to trigger release from hydrogels containing gas vesicles, demonstrating targeted delivery in a rat colitis model.

This paper introduces nonlinear singular value decomposition beamforming for ultrasound imaging of gas vesicles, achieving comparable sensitivity to existing methods with fewer pulse transmissions and improved signal-to-background ratio.

This paper introduces DSR, an ultrasound imaging method that super-resolves individual cells using acoustic deactivation of genetically encoded contrast agents, demonstrating its ability to localize mammalian cells beyond conventional resolution.

VARS-fUSI improves functional ultrasound imaging efficiency by reducing sampling time and rate while maintaining signal quality and enabling cross-species generalization.

This paper introduces nonlinear sound-sheet microscopy to image opaque organs at the capillary and cellular scale, achieving faster imaging speed, larger volume, and higher resolution than existing biomolecular ultrasound techniques.

The paper identifies a population code in VMHdmSF1 neurons that encodes predator imminence and internal states during predator encounters in mice.

This study characterizes gas vesicles as cavitation nuclei for ultrasound therapy using passive acoustic mapping and finds that cavitation activity diminishes rapidly after the first pulse.

This study introduces harmonic xAM (HxAM) imaging to improve GV detection sensitivity and imaging depth in vivo.

This paper develops a non-invasive ultrasound-based method to track cell-based therapies using acoustic reporter genes in primary mammalian cells.

The paper evolves acoustic reporter genes using high-throughput acoustic screening to enhance nonlinear ultrasound scattering.

The paper uses functional ultrasound imaging to map directional tuning in the lateral intraparietal area, revealing mesoscopic organization of saccade directions across posterior parietal cortex.

This paper introduces a permanent acoustic window for high-resolution, non-invasive ultrasound imaging of human brain activity, demonstrating its use in mapping cortical responses to finger movement.