Pharmacology & ToxicologybioRxivPreprint
Identification of a pharmacokinetic interaction between teicoplanin and sulfo-butyl ether-beta-cyclodextrin, an excipient in the intravenous posaconazole formulation
Yoshimasa Adachi, Mitsuhiro Sugimoto, Yusei Yamada…·Tomohiro Terada
The paper identifies a pharmacokinetic interaction between teicoplanin and SBECD, an excipient in posaconazole, showing reduced TEIC protein binding and increased renal excretion in rats and patients.
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