HIF-1α and HIF-2α transcription factors differentially regulate lung alveolar macrophage function
Elena Priego, Irene Adán‐Barrientos, Ruth Conde‐Garrosa, Sarai Martínez-Cano, Iria Sánchez, Diego Mañanes, Annalaura Mastrangelo, Joaquín Amores, Helena M. Izquierdo, David Sancho
This study shows HIF-1α and HIF-2α differentially regulate lung alveolar macrophage function, with HIF-2α playing a central role in impaired maturation and surfactant clearance.
bioRxiv · Nov 25, 2025 · PreprintPhysiology