Diego Mañanes

OmniPath Metabo integrates metabolomics data with prior knowledge to enable mechanistic analysis of the metabolome through harmonized databases and network construction.

This study shows HIF-1α and HIF-2α differentially regulate lung alveolar macrophage function, with HIF-2α playing a central role in impaired maturation and surfactant clearance.

OmniPath integrates molecular knowledge from 168 resources to support multi-omics analysis, offering curated data, predictions, and tools for causal modeling across bulk, single-cell, and spatial data.

The paper introduces COSMOS+ to integrate mechanistic prior knowledge with multi-omics data analysis to generate mechanistic hypotheses about disease resistance mechanisms.

SpatialDDLS deconvolutes spatial transcriptomics data using neural networks, showing accuracy and speed compared to existing methods.