David Sancho

This study shows mitochondrial haplogroups affect tumour growth and anti-tumour immunity through mitochondrial ROS and PD-1 signalling in mouse models.

This study shows that age-related decline in adipose tissue lipolysis reduces disease tolerance to SARS-CoV-2, increasing mortality in older mice and correlating with human COVID-19 severity.

This study identifies BATF3 as a critical regulator of innate-like γδ T cell homeostasis, function, and tissue distribution, revealing its role in survival, IL-17 production, and immune responses.

This study shows HIF-1α and HIF-2α differentially regulate lung alveolar macrophage function, with HIF-2α playing a central role in impaired maturation and surfactant clearance.

The paper evaluates how Hiltonol and protamine-RNA stimulate human cDC1s, showing similar transcriptome changes related to immune activation without synergistic effects.

This study shows that monocyte-derived macrophages regulate energy homeostasis by responding to iron metabolism dysregulation in parenchyma cells.

This study shows that gut Enterococcus faecalis induces trained immunity in myeloid bone marrow progenitors via the C-type lectin receptor Mincle, contributing to inflammation linked to gut permeability.

SpatialDDLS deconvolutes spatial transcriptomics data using neural networks, showing accuracy and speed compared to existing methods.