Michael Francis

Combinatorial effects of gene dosage, polygenic background and environment on complex traits

The paper examines how gene dosage, polygenic background, and environment influence complex traits like height and BMI using large-scale data from multiple cohorts.

Methylation profiling in the Million Veteran Program: design, quality control, and smoking-associated epigenetic signatures

The paper describes methylation profiling in the Million Veteran Program, identifies smoking-associated epigenetic signatures, and reports novel probe-smoking associations through ancestry-stratified EWAS.

Genome-wide association study of dry eye disease reveals shared heritability with systemic comorbidities

This study identifies ten genetic loci associated with dry eye disease and finds significant genetic correlations with several comorbidities.

Multi-ancestry meta-analyses of lung cancer in the Million Veteran Program reveal novel risk loci and elucidate smoking-independent genetic risk

The paper identifies twelve novel genetic risk loci for lung cancer subtypes through multi-ancestry GWAS and shows smoking-independent genetic risk.

Multi-ancestry genome-wide association meta-analysis of mosaic loss of chromosome Y in the Million Veteran Program identifies 240 novel loci

This study identifies 240 novel genetic loci associated with mosaic loss of chromosome Y through a multi-ancestry GWAS of the Million Veteran Program and UK Biobank.

Shared genetic basis informs the roles of polyunsaturated fatty acids in brain disorders

The paper examines the shared genetic basis between polyunsaturated fatty acids and brain disorders using genome-wide association data and identifies causal relationships and shared variants.

The Causal Effects of Blood Iron and Copper on Lipid Metabolism Disease: Evidence from Phenome-wide Mendelian Randomization Study

This study uses Mendelian randomization to show higher blood iron and copper levels are associated with lower risks of lipid metabolism disorders and related conditions.