Giant extrachromosomal element "Inocle" potentially expands the adaptive capacity of the human oral microbiome
Yuya Kiguchi, Nagisa Hamamoto, Yukie Kashima, Lucky Ronald Runtuwene, Aya Ishizaka, Yuta Kuze, Tomohiro Enokida, Nobukazu Tanaka, Makoto Tahara, Shun‐Ichiro Kageyama, Takao Fujisawa, Riu Yamashita, Akinori Kanai, Josef S. B. Tuda, Taketoshi Mizutani, Yutaka Suzuki
The paper identifies a novel giant extrachromosomal element, Inocles, prevalent in the human oral microbiome that contributes to bacterial stress tolerance and may serve as a biomarker for gastrointestinal cancers.
Nature Communications · Aug 11, 2025Peer-reviewedGenomics