Takao Fujisawa

SPATNIC is a variational autoencoder that identifies cancer cells from spatial and single-cell transcriptomic data in colorectal cancer, outperforming existing tools and identifying a rare cancer stem cell population.

The paper analyzes gut microbiota changes across 264 cancer patients treated with 22 anticancer drugs, finding drug-specific and treatment-related microbiota alterations.

The paper identifies a novel giant extrachromosomal element, Inocles, prevalent in the human oral microbiome that contributes to bacterial stress tolerance and may serve as a biomarker for gastrointestinal cancers.