Akinori Kanai

This study identifies key ACE2 residues that influence sarbecovirus infectivity in African Rhinolophus bats and reports novel ACE2 sequences from R. simulator and R. blasii.

This study identifies calmodulin as a host factor that accelerates HSV-1 gene-expression tempo, increasing virus-producing cells and protecting mice from lethal infection.

The paper identifies ALBA proteins that form stress-inducible nuclear condensates to suppress gene inducibility during osmotic stress in plants.

StateMap integrates CRISPR fitness and gene expression data to map cancer pathway states, identifying therapeutic vulnerabilities in the Hippo pathway.

This study compares transcriptomes of cultured and in vivo chicken primordial germ cells using single-cell RNA sequencing, revealing shifts in gene regulatory networks and new intermediate cell states.

This study identifies CD55 and CD248 as novel surface markers for tendon stem/progenitor cells using single-cell and single-nucleus sequencing in mouse Achilles tendon.

The paper maps lineage trajectories and gene regulatory networks of cardiopharyngeal neural crest cells in mice, identifying a Hox-Meis-regulated transition associated with cardiac cushion development.

The paper identifies a novel giant extrachromosomal element, Inocles, prevalent in the human oral microbiome that contributes to bacterial stress tolerance and may serve as a biomarker for gastrointestinal cancers.

This study shows JMJD3 promotes senescence in HSPCs to overcome stress-induced hematopoietic defects, with implications for aging and cancer therapies.

This study identifies Muc6-expressing isthmus progenitors as key contributors to gastric regeneration and metaplasia through myeloid-mesenchymal interactions.

This study shows that TNF inhibitor infliximab reduces tertiary lymphoid structures and alleviates Crohn's disease inflammation by targeting follicular dendritic cells and macrophages.

The paper identifies PTBP1 as responsible for caspase-dependent YRNA cleavage during apoptosis, revealing its role in ASR biogenesis.