Author

Bruce E. Seligmann

Biospyder (United States)ORCID 0000-0002-1342-801XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Dennis J. EastburniD· 2 shared Gioele Montis· 2 shared Joanne M. YeakleyiD· 2 shared Joel McComb· 2 shared Kevin S. WhiteiD· 2 shared Salvatore CamioloiD· 2 shared Brian N. ChorleyiD· 1 shared Brian Robinette· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersPharmacology & Toxicology

Dennis J. EastburnORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Pharmacology & ToxicologyNAM journal.Peer-reviewedJan 1, 2025

Decoding Cellular Stress States for Toxicology Using Single-Cell Transcriptomics

Imran Shah, David A. Gallegos, Brian Robinette…·Brian N. Chorley

The paper uses single-cell transcriptomics to analyze stress responses in HepaRG cells exposed to various chemicals, identifying distinct phenotypic groups and dynamic shifts in cellular subpopulations.

3 citations

humanscRNA-seq

𝕏 PostBluesky

GenomicsScientific ReportsPeer-reviewedDec 28, 2024

High-throughput gene expression analysis with TempO-LINC sensitively resolves complex brain, lung and kidney heterogeneity at single-cell resolution

Dennis J. Eastburn, Kevin S. White, Nathan D. Jayne…·Bruce E. Seligmann

This paper introduces TempO-LINC, a high-throughput single-cell transcriptomic platform that resolves complex tissue heterogeneity in brain, lung, and kidney tissues with high sensitivity and scalability.

2 citations

mousescRNA-seq

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GenomicsPLoS ONEPeer-reviewedFeb 22, 2019

Extraction-Free Whole Transcriptome Gene Expression Analysis of FFPE Sections and Histology-Directed Subareas of Tissue

Christy L. Trejo, Miloš Babić, Elliot Imler…·Bruce E. Seligmann

The paper describes a method to analyze gene expression in FFPE tissues without RNA extraction, showing high correlation with fresh samples and consistent performance across species and tissue areas.

48 citations

humanmouse

𝕏 PostBluesky