Author

Dennis J. Eastburn

Biospyder (United States)ORCID 0009-0003-1514-5544Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genomics· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:clustering· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Bruce E. SeligmanniD· 2 shared Gioele Montis· 2 shared Joel McComb· 2 shared Kevin S. WhiteiD· 2 shared Salvatore CamioloiD· 2 shared Adam SciambiiD· 1 shared Brian N. ChorleyiD· 1 shared Brian Robinette· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPharmacology & Toxicology

Bruce E. SeligmannORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pharmacology & ToxicologyNAM journal.Peer-reviewedJan 1, 2025

Decoding Cellular Stress States for Toxicology Using Single-Cell Transcriptomics

Imran Shah, David A. Gallegos, Brian Robinette…·Brian N. Chorley

The paper uses single-cell transcriptomics to analyze stress responses in HepaRG cells exposed to various chemicals, identifying distinct phenotypic groups and dynamic shifts in cellular subpopulations.

3 citations

humanscRNA-seq

𝕏 PostBluesky

GenomicsScientific ReportsPeer-reviewedDec 28, 2024

High-throughput gene expression analysis with TempO-LINC sensitively resolves complex brain, lung and kidney heterogeneity at single-cell resolution

Dennis J. Eastburn, Kevin S. White, Nathan D. Jayne…·Bruce E. Seligmann

This paper introduces TempO-LINC, a high-throughput single-cell transcriptomic platform that resolves complex tissue heterogeneity in brain, lung, and kidney tissues with high sensitivity and scalability.

2 citations

mousescRNA-seq

𝕏 PostBluesky

GenomicsGenome ResearchPeer-reviewedSep 1, 2018

High-throughput single-cell DNA sequencing of AML tumors with droplet microfluidics

Maurizio Pellegrino, Adam Sciambi, Sebastian Treusch…·Dennis J. Eastburn

This study develops a microfluidic method for single-cell DNA sequencing of AML tumors, revealing clonal evolution not detectable by bulk sequencing.

229 citations

humanwhole-genome sequencing

𝕏 PostBluesky