BiochemistryNature CommunicationsPeer-reviewed
The oncogenic CCDC6-RET fusion product is a dual ATP and ADP-dependent kinase that functions via cis-phosphorylation
Ana Martín-Hurtado, Julia Contreras, Jana Sánchez…·Iván Plaza-Menacho
This study identifies CCDC6-RET as a dual ATP/ADP-dependent kinase with a unique dimeric structure and phosphorylation mechanism, revealing structural and functional determinants of its oncogenic activity.
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