HLH-30/TFEB rewires the chaperone network to promote proteostasis under conditions of Coenzyme A and Iron-Sulfur Cluster Deficiency
Rewayd Shalash, Dror Michael Solomon, Mor Levi‐Ferber, Henrik von Chrzanowski, Mohammad Khaled Atrash, Barak Nakar, Matan Yosef Avivi, Hagit Hauschner, Aviya Swisa, Alicia Meléndez, Yaron Shav‐Tal, Sivan Henis‐Korenblit
The paper shows that reducing Coenzyme A and iron-sulfur cluster levels enhances proteostasis in C. elegans and human cells via HLH-30/TFEB activation of chaperone genes.
Aging Cell · Apr 30, 2025Peer-reviewedCell Biology