Author

James F. Conley

Boston UniversityORCID 0000-0002-1366-4231Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

James Halley McNeelyiD· 1 shared Jerry PelletieriD· 1 shared John A. Jr. PorcoiD· 1 shared Karen N. AlleniD· 1 shared Lauren E. BrowniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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1 shared paperBiochemistry

James Halley McNeelyORCID

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1 paper

Recent·Most cited

Structural Basis for the Improved RNA-Clamping of Amidino-Rocaglates to eIF4A1

James F. Conley, Lauren E. Brown, James Halley McNeely, Jerry Pelletier, John A. Jr. Porco, Karen N. Allen

This paper presents the X-ray structure of an amidino-rocaglate in complex with eIF4A1 and RNA, showing how its rigid scaffold improves RNA-clamping compared to rocaglamide A.

ACS Omega · Feb 10, 2025Peer-reviewedBiochemistry