Jerry Pelletier

This paper presents the X-ray structure of an amidino-rocaglate in complex with eIF4A1 and RNA, showing how its rigid scaffold improves RNA-clamping compared to rocaglamide A.

The paper identifies the mTORC1/S6K/PDCD4/eIF4A axis as critical for determining cell fate during mitotic arrest, showing that disrupting this pathway can enhance the effectiveness of anti-mitotic drugs.

This study shows that de novo protein synthesis in specific CeL interneurons is required for storing threat memories and response inhibition.

This study investigates the dimerization interface of wild-type IFIT1 and its role in RNA binding and antiviral function.