Structural basis for hydrolytic splicing of a circularly permuted group II intron
Xiaobin Ling, Yuqi Yao, Dmitrij Golovenko, Kangkang Song, Chen Xu, Jianhua Gan, Zhenguo Chen, Jinbiao Ma
This study presents cryo-EM structures of a circularly permuted group II intron, revealing the mechanism of the hydrolysis pathway and its regulation by branch point and splice site mutations.
bioRxiv · Feb 7, 2026 · PreprintBiophysics