Author

Chen Xu

University of Massachusetts Chan Medical School

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Bioinformatics· 1 Biophysics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Kangkang SongiD· 2 shared Brian A. KelchiD· 1 shared Dmitrij GolovenkoiD· 1 shared Dongyang LiiD· 1 shared Emily AgnelloiD· 1 shared Emma L. SedivyiD· 1 shared Guo Zhenli· 1 shared Huanxiang LiuiD· 1 shared

Activity by Year

2023-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiophysics

Kangkang SongORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The mechanism of Hsa_circ_0000629 in bronchial asthma through sponge adsorption of miR-212-5p/NLRP3

Su Xiandu, Lin Lieju, Yu Li, Guo Zhenli, Lin Mingli, Zeng Guidan, Chen Xu, Dongyang Li

This study investigates how Hsa_circ_0000629 regulates bronchial asthma by sponging miR-212-5p to modulate NLRP3 expression, leading to reduced inflammation and apoptosis.

bioRxiv · Mar 24, 2026 · PreprintImmunology

Structural basis for hydrolytic splicing of a circularly permuted group II intron

Xiaobin Ling, Yuqi Yao, Dmitrij Golovenko, Kangkang Song, Chen Xu, Jianhua Gan, Zhenguo Chen, Jinbiao Ma

This study presents cryo-EM structures of a circularly permuted group II intron, revealing the mechanism of the hydrolysis pathway and its regulation by branch point and splice site mutations.

bioRxiv · Feb 7, 2026 · PreprintBiophysics

The structure of a thermostable phage's Portal Vertex and Neck Complex illuminates the headful maturation mechanism

Emma L. Sedivy, Emily Agnello, Julia E. Hobaugh, Rakeyah Ahsan, Kangkang Song, Chen Xu, Brian A. Kelch

The paper determines the structure of the portal vertex and neck complex in the hyperthermophilic phage Oshimavirus, revealing a pressure-sensitive mechanism for terminating DNA packaging and triggering tail attachment.

Journal of Molecular Biology · Jan 14, 2026Peer-reviewedMicrobiology

A versatile framework for drug-target interaction prediction by considering domain specific features

Shuo Liu, Jialiang Yu, Ningxi Ni, Zidong Wang, Mengyun Chen, Yuquan Li, Chen Xu, Yahao Ding, Jun Zhang, Xiaojun Yao, Huanxiang Liu

This paper introduces E-DIS, a framework for drug-target interaction prediction that improves generalization to out-of-distribution data by combining domain-specific and domain-generic features.

bioRxiv · Aug 1, 2023 · PreprintBioinformatics