Olga Burmistrova

This paper develops a deep learning model to identify a blood-based biomarker of aging in mice using phenotypic data, finding it correlates with aging hallmarks and predicts lifespan.

This study identifies a metabolic shift driven by PFKFB3 in CLN7 disease, showing that targeting glycolysis can alleviate disease hallmarks in a mouse model and patient-derived cells.

This study shows that inhibiting PFKFB3 in neurons prevents redox stress and neuronal death in ischemia-reperfusion injury, and reduces brain damage in mice.