The paper identifies a female-specific microglial redox program that influences susceptibility to obesity by modulating metabolic resilience and mTORC1 signaling.

bioRxiv · Sep 9, 2026 · PreprintNeuroscience

Long-term disruption of glucose homeostasis in a rodent model of preterm birth.

Sihao Diao, David Guenoun, Shiou-Ping Chen, Céline Cruciani-Guglielmacci, Julien Pansiot, Mireille Laforge, Ilyes Raho, Valérie Faivre, Vincent Degos, Pierre Gressens, Agnès Nadjar, Juliette Van Steenwinckel, Homa Adle-Biassette, Christophe Magnan, Alice Jacquens, Cindy Bokobza

This study investigates the long-term metabolic effects of perinatal inflammation in mice, finding sex-dependent glucose metabolism dysregulation and potential therapeutic implications.

bioRxiv · Feb 7, 2024 · PreprintPhysiology

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain

Charlotte Madore, Quentin Leyrolle, L. Morel, Jean-Christophe Delpech, Andrew D. Greenhalgh, Chloé Lacabanne, Clémentine Bosch‐Bouju, Julien Bourel, Aurore Thomazeau, Kathryn E. Hopperton, Sol Beccari, A. Séré, A. Aubert, Véronique De Smedt, Cynthia Lecours, , Sophie Layé

Low maternal omega-3 fatty acid intake impairs microglia-mediated synaptic refinement via the 12-HETE pathway in the developing brain.

bioRxiv · Sep 4, 2019 · PreprintNeuroscience