p53 preserves genome stability in dividing cells under hypo-osmotic stress
Bin Sheng Wong, Alokendra Kumar Ghosh, Hongyue Cui, Keming Li, Blake A. Johnson, Kriti Sethi, Yaelim Lee, Jin Zhu, Sean X. Sun, Rong Li
This study shows that p53 prevents genome instability by halting cell division under hypo-osmotic stress through G1 arrest and downstream gene activation.
bioRxiv · Dec 18, 2025 · PreprintCell Biology