Jin Zhu

Enzymatic extracellular matrix remodeling in ex vivo slices of aged myocardium

This study shows enzymatic remodeling of aged cardiac ECM reduces stiffness but preserves contractility and some age-related transcriptional features in ex vivo myocardial slices.

Rapid Bacterial Identification through Biophysical Surface Topography Features

This study identifies bacterial genera using 3D surface topography features with 97% accuracy, showing taxonomic information persists at the population morphology level.

Mechanical Memory Primes Cells for Confined Migration

This study investigates mechanical memory in cells, showing that stiffness-sensitive cells improve confined migration after prior exposure to soft substrates, mediated by NFATC2.

Cep192 insufficiency underlies haploid instability in human cells

This study identifies Cep192 insufficiency as a cause of haploid instability in human cells and shows that restoring Cep192 or enhancing the acentrosomal spindle pathway stabilizes haploid cells.

p53 preserves genome stability in dividing cells under hypo-osmotic stress

This study shows that p53 prevents genome instability by halting cell division under hypo-osmotic stress through G1 arrest and downstream gene activation.

Extracellular matrix deposition controls early differentiation patterns in human cardiac gastruloids

This study shows that extracellular matrix deposition patterns influence early differentiation in human cardiac gastruloids by shaping spatial organization and cell behavior.