Sean X. Sun

Mechanochemical cues control the coupling of metabolic and migratory patterns in cancer

The paper shows that cancer cells switch between glycolysis and oxidative phosphorylation based on microenvironment stiffness, affecting their migration patterns.

Whole organism 3D mapping reveals universal branching topology and biophysical optimization governs vascular and nervous system development

The paper uses 3D imaging to analyze vascular and nervous systems in embryos, finding shared structural principles but distinct architectures shaped by biophysical constraints.

Cell-nanoplastics association impacts cell proliferationand motility

This study quantitatively investigates how different nanoplastics associate with and affect diverse cell types, revealing cell-type-dependent impacts on proliferation and motility.

Acute priming using elevated fluid viscosity recovers young-like single-cellsurveillance behaviors in aged human T cells

This study shows that increasing fluid viscosity can temporarily restore young-like surveillance behaviors in aged human T cells by improving deformability and sensing.

Cancer cells surviving cisplatin chemotherapy increase stress-induced OMA1 activity and mitochondrial fragmentation

This study shows that cancer cells surviving cisplatin chemotherapy increase OMA1 activity and mitochondrial fragmentation to resist oxidative stress.

p53 preserves genome stability in dividing cells under hypo-osmotic stress

This study shows that p53 prevents genome instability by halting cell division under hypo-osmotic stress through G1 arrest and downstream gene activation.

Anionic Lipid Trafficking and Cell Mechanics RegulateMembrane Electrical Potential in Non-Excitable Tissue Cells

This study shows that non-excitable cells have spatially varying membrane potentials linked to anionic lipid distribution and mechanical factors, challenging the traditional view of membrane potential regulation.

Chemical Compensation to Mechanical Loss in CellMechanosensation

This study identifies a chemical compensation mechanism in cells responding to mechanical stimuli, revealing non-monotonic changes in volume and pH mediated by PI3K/Akt and MAPK/ERK pathway interactions.

Cells Prioritize the Regulation of Cell Mass Density

The paper investigates cell mass density (CMD) dynamics after osmotic shock and finds CMD recovers monotonically through coordinated protein synthesis and volume growth, with NHE playing a regulatory role.

Cell-Driven Fluid Dynamics: A Physical Model of Active Systemic Circulation

The paper develops a mathematical model that integrates pressure and osmolarity gradients in systemic circulation, showing how cell properties influence transport and vice versa.

From Decay to Rhythm: Coherent Biological Oscillators Require More Than Chemistry Alone

This paper proposes a mechanism to achieve noise-resistant coherent oscillations by coupling a Markovian system to a non-Markovian system, validated through a trimolecular reaction system.

Solving the "Blind men and the elephant problem": Additive deep learning of complex high dimensional models from partial faceted datasets

The paper develops a machine learning approach to reconstruct complex biological systems from partial faceted datasets, showing successful reconstruction in both mechanical and biological examples.

Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblasts

This study shows that substrate stiffness affects the development and strength of senescence features in fibroblasts, with mechanosensitive regulation of key biomarkers.