Rong Li

Paired-surface spatial mechanomics links tissue stiffness maps to spatial transcriptomics

Ovarian extracellular matrix mechanics regulate oocyte-follicle interactions during female reproductive aging

This study shows that increased ovarian ECM stiffness with age impairs follicle function by reducing granulosa cell proliferation and oocyte quality through TGF-β signaling.

p53 preserves genome stability in dividing cells under hypo-osmotic stress

This study shows that p53 prevents genome instability by halting cell division under hypo-osmotic stress through G1 arrest and downstream gene activation.

The scaffold protein PRR14L links the PP2A-TACC3 axis to mitotic fidelity and sensitivity to MPS1 inhibition

The paper identifies PRR14L as a gene affecting mitotic fidelity and sensitivity to MPS1 inhibition through a CRISPR/Cas9 screen and proximity labeling.

Spatiotemporal coordination of actin regulators generates invasive protrusions in cell-cell fusion

The paper identifies the spatiotemporal coordination of WAVE and N-WASP with actin-bundling proteins to generate invasive protrusions during cell-cell fusion.

Branched actin polymerization drives invasive protrusion formation to promote myoblast fusion during skeletal muscle regeneration

This study identifies branched actin polymerization as essential for myoblast fusion during skeletal muscle regeneration, showing its role in forming invasive protrusions for fusion.

Rejuvenation of aged oocyte through exposure to young follicular microenvironment

This study shows that exposing aged oocytes to a young follicular environment improves their maturation, developmental potential, and mitochondrial function.

R-Loop Functions in Brca1-Associated Mammary Tumorigenesis

This study shows that reducing R-loops in Brca1-knockout mice increases ER-expressing tumors but does not affect tumor incidence.

A novel multifunctional role for Hsp70 in binding post-translational modifications on clients

This paper uses cross-linking mass spectrometry to characterize Hsp70 interactions in budding yeast, revealing self-association, multi-point client interactions, and novel PTMs critical for client function.

Predicting complex genetic phenotypes using error propagation in weighted networks

The paper uses weighted networks with non-linear activation functions to predict gene essentiality in yeast and suggests biological networks function as distributed systems with unreliable components.