Functional Recovery from Human Induced Pluripotent Stem Cell-Derived Dopamine Neuron Grafts is Dependent on Neurite Outgrowth
Rachel Hills, Jim A. Mossman, Andrés M. Bratt‐Leal, Ha Tran, Roy M. Williams, David G. Stouffer, Irina V. Sokolova, Pietro Paolo Sanna, Jeanne F. Loring, Mariah J. Lelos
This study shows that functional recovery from dopamine neuron grafts depends on neurite outgrowth, not graft size or neuron content, and identifies gene expression patterns linked to graft efficacy.
bioRxiv · Apr 19, 2022 · PreprintNeuroscience