David M. Rand

This study examines how mTOR-mediated transcriptional regulation diverges between Drosophila melanogaster and Drosophila simulans across tissues and sexes, finding tissue- and sex-specific evolutionary divergence.

The paper tests the Mothers Curse hypothesis by comparing mtDNA effects on performance traits in Drosophila across different nuclear backgrounds, finding greater phenotypic variation in females than males, contrary to the hypothesis.

The paper quantifies the relative contributions of mitochondrial, nuclear, and environmental variation to complex traits in Drosophila, finding that genetic and environmental interactions outweigh mitonuclear coevolution.

The paper identifies a genetic locus, iPLA2-VIA, contributing to starvation sensitivity in Drosophila by analyzing mitonuclear genotypes and metabolic changes.

The paper identifies genetic modifiers of flight performance robustness in Drosophila using DGRP lines and finds genes involved in proprioception influence both trait mean and variance.

The paper identifies genetic modifiers of flight performance in Drosophila using the DGRP, finding additive and epistatic variants, whole genes, and network interactions, with implications for neurodevelopment and neurodegeneration.

The paper identifies genetic factors influencing robustness of flight performance in Drosophila using association analyses across multiple genetic models.

FreeClimber quantifies climbing velocity for Drosophila cohorts, eliminating systematic biases of manual methods through automated and high-throughput analysis.