Author

Laurens Lambrechts

Ghent University HospitalORCID 0000-0002-1415-4591Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:variant calling· 3 Assay:long-read sequencing· 2 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

Linos VandekerckhoveiD· 2 shared Sofie RutsaertiD· 2 shared Ytse Noppe· 2 shared Amber VerhasseltiD· 1 shared Ana Lucia Rocha IraizosiD· 1 shared Basiel ColeiD· 1 shared Christopher DaviesiD· 1 shared Evelien De Smet· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMolecular Biology

Linos VandekerckhoveORCID

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3 papers

Recent·Most cited

LRSomatic: a highly scalable and robust pipeline for somatic variant calling in long-read sequencing data

Robert A. Forsyth, Luuk Harbers, Amber Verhasselt, Ana Lucia Rocha Iraizos, Sidi Yang, Joris Vande Velde, Christopher Davies, Nischalan Pillay, Laurens Lambrechts, Jonas Demeulemeester

LRSomatic is a pipeline for somatic variant calling in long-read sequencing data, achieving state-of-the-art performance on cancer samples and resolving complex variants.

bioRxiv · Feb 28, 2026 · PreprintBioinformatics

Integrative assessment of total and intact HIV-1 reservoir by a five-region multiplexed Rainbow digital PCR assay

Mareva Delporte, Laurens Lambrechts, Evy E. Blomme, Willem van Snippenberg, Sofie Rutsaert, Maxime Verschoore, Evelien De Smet, Ytse Noppe, Nele De Langhe, Marie‐Angélique De Scheerder, Sarah Gerlo, Linos Vandekerckhove, Wim Trypsteen

The paper develops a multiplexed digital PCR assay to quantify total and intact HIV-1 reservoirs, showing it is more specific than existing methods and enables high-throughput analysis.

Clinical Chemistry · Dec 3, 2024Peer-reviewedMolecular Biology

HIV-PULSE: A long-read sequencing assay for high-throughput near full-length HIV-1 proviral genome characterization

Laurens Lambrechts, Noah Bonine, Rita Verstraeten, Marion Pardons, Ytse Noppe, Sofie Rutsaert, Filip Van Nieuwerburgh, Wim Van Criekinge, Basiel Cole, Linos Vandekerckhove

HIV-PULSE is a long-read sequencing assay that enables high-throughput, accurate characterization of HIV-1 proviral genomes without limiting dilution steps.

Nucleic Acids Research · Sep 19, 2023Peer-reviewedMolecular Biology