Author

Matthew Valle Holt

Baylor College of MedicineORCID 0000-0002-1418-6139Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Amanda M. KoireiD· 1 shared Angela D. Wilkins· 1 shared Bin YangiD· 1 shared Bing ZhangiD· 1 shared Brigitta WastuwidyaningtyasiD· 1 shared Byung Kwon Choi· 1 shared Chih-Hsu LiniD· 1 shared Daniel M. KoneckiiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBioinformatics

Amanda M. KoireORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedSep 30, 2025

COOKIE-Pro: Covalent Inhibitor Binding Kinetics Profiling on the Proteome Scale

Hanfeng Lin, Bin Yang, Lang Ding…·Jin Wang

COOKIE-Pro quantifies covalent inhibitor binding kinetics across the proteome, revealing off-targets and kinetic parameters for BTK inhibitors.

8 citations

proteomicsexperimental assay

𝕏 PostBluesky

BioinformaticsbioRxivPreprintAug 29, 2018

Automated literature mining and hypothesis generation through a network of Medical Subject Headings

Stephen Joseph Wilson, Angela D. Wilkins, Matthew Valle Holt…·Olivier Lichtarge

This paper introduces MeTeOR, a method using MeSH terms to generate hypotheses from PubMed literature, showing improved reliability over existing methods and validating a new EGFR-CDK2 association.

11 citations

statistical modelbenchmark study

𝕏 PostBluesky