Lang Ding

The paper compares five quantitative proteomic methods to identify high-confidence longevity regulators in C. elegans by analyzing IIS mutants.

This paper uses ex utero culture to study mouse embryogenesis from gastrulation to fetal development, revealing metabolically independent programs and environmental influences on metabolic transitions.

COOKIE-Pro quantifies covalent inhibitor binding kinetics across the proteome, revealing off-targets and kinetic parameters for BTK inhibitors.

TEMI maps biomolecule distributions in tissues at single-cell resolution, revealing metabolic heterogeneity in tumors.

This paper develops a first-in-class RIPK1 degrader, LD4172, which enhances antitumor immunity by promoting immunogenic cell death and sensitizing tumors to anti-PD1 therapy.

This study identifies SLC29A homologs in C. elegans that mediate nucleoside coordination between soma and germline, revealing guanosine as critical for reproduction.