Author

Amalia R. Sweet

Beth Israel Deaconess Medical CenterORCID 0000-0002-1418-9989Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:scRNA-seq· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Steven P. BalkiD· 2 shared Abhay KanodiaiD· 1 shared Adam G. SowalskyiD· 1 shared Alice Bosma-Moody· 1 shared Alok K. TewariiD· 1 shared Asaf RotemiD· 1 shared Aviv RegeviD· 1 shared Benjamin IzariD· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersGenomics

Steven P. BalkORCID

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2 papers

Recent·Most cited

Transcriptional mediators of treatment resistance in lethal prostate cancer

Meng Xiao He, Michael S. Cuoco, Jett P. Crowdis, Alice Bosma-Moody, Zhenwei Zhang, Kevin Bi, Abhay Kanodia, Mei-Ju Su, Sheng‐Yu Ku, Maria Mica Garcia, Amalia R. Sweet, Christopher Rodman, Laura K. DelloStritto, Rebecca Silver, John A. Steinharter, , Eliezer M. Van Allen

This study identifies transcriptional states in mCRPC that mediate treatment resistance, including AR splicing heterogeneity, TGF-β signaling, and immune infiltration patterns.

Nature Medicine · Mar 1, 2021Peer-reviewedGenomics

Low abundance of circulating tumor DNA in localized prostate cancer

S. Thomas Hennigan, Shana Y. Trostel, Nicholas Taylor Terrigino, Olga S. Voznesensky, Rachel J. Schaefer, Nichelle C. Whitlock, Scott C. Wilkinson, Nicole V. Carrabba, Rayann Atway, Steven Shema, Ross G. Lake, Amalia R. Sweet, David Johnson Einstein, Fatima H. Karzai, James L. Gulley, , Adam G. Sowalsky

The paper shows that ctDNA is undetectable in localized prostate cancer but present in metastatic cases, suggesting lower dissemination and detectability in early stages.

JCO Precision Oncology · Sep 9, 2019Peer-reviewedGenomics