Fatima H. Karzai

Histone modifications define distinct nucleosome positions in cell-free DNA

This paper identifies histone modification-associated nucleosome positions in cfDNA that correlate with tumor fraction and cancer state across multiple cancers.

Androgen deprivation-mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion

This study shows that in prostate cancer with TMPRSS2:ERG fusion, androgen deprivation increases AKT activation, which may reduce the effectiveness of AR-targeted therapy, suggesting combination therapy could be beneficial.

Clinically oriented prediction of patient response to targeted and immunotherapies from the tumor transcriptome

ENLIGHT predicts patient response to targeted and immunotherapies using tumor transcriptomes without prior treatment response data, showing better accuracy than existing transcriptomics-based signatures.

Low abundance of circulating tumor DNA in localized prostate cancer

The paper shows that ctDNA is undetectable in localized prostate cancer but present in metastatic cases, suggesting lower dissemination and detectability in early stages.