Author

Alice Bosma-Moody

Allen Institute for Brain Science

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4 Genomics· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell-cell communication· 3 Organism:human· 3 Assay:imaging· 2 Approach:statistical model· 2 Research Focus:differential expression· 1

Frequent Co-Authors

Christopher A. BakeriD· 4 shared Gabe J. MurphyiD· 4 shared Hongkui ZengiD· 4 shared Travis A HageiD· 4 shared Bosiljka TasiciD· 2 shared David LiuiD· 2 shared Ed S. LeiniD· 2 shared Eliezer M. Van AlleniD· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersNeuroscience

Christopher A. BakerORCID

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Author profile →

6 papers

Recent·Most cited

Mutational footprint of platinum chemotherapy in a secondary thyroid cancer

Julia Schiantarelli, Θεοδώρα Παππά, Jake R. Conway, Jett P. Crowdis, Brendan Michael Reardon, Felix Dietlein, Julian Huang, Darren A. Stanizzi, Evan Carey, Alice Bosma-Moody, Alma Imamović, Seunghun Han, Sabrina Yvonne Camp, Eric R. Kofman, Erin E. Shannon, , Eliezer M. Van Allen

This paper reports a case where platinum chemotherapy exposure was linked to the development of aggressive thyroid cancer through mutational signatures and genomic analysis.

JCO Precision Oncology · Aug 1, 2022Peer-reviewedGenomics

Distribution and strength of interlaminar synaptic connectivity in mouse primary visual cortex revealed by two-photon optogenetic stimulation

Travis A Hage, Alice Bosma-Moody, Christopher A. Baker, Megan B. Kratz, Luke Campagnola, Tim Jarsky, Hongkui Zeng, Gabe J. Murphy

The paper measures synaptic inputs onto superficial excitatory neurons in mouse primary visual cortex using two-photon optogenetic stimulation and finds that layer 4 excitatory neurons and somatostatin-neurons in layer 2/3 are the most common sources of input, with strong connections distributed across cells.

eLife · Jan 21, 2022Peer-reviewedNeuroscience

Transcriptional mediators of treatment resistance in lethal prostate cancer

Meng Xiao He, Michael S. Cuoco, Jett P. Crowdis, Alice Bosma-Moody, Zhenwei Zhang, Kevin Bi, Abhay Kanodia, Mei-Ju Su, Sheng‐Yu Ku, Maria Mica Garcia, Amalia R. Sweet, Christopher Rodman, Laura K. DelloStritto, Rebecca Silver, John A. Steinharter, , Eliezer M. Van Allen

This study identifies transcriptional states in mCRPC that mediate treatment resistance, including AR splicing heterogeneity, TGF-β signaling, and immune infiltration patterns.

Nature Medicine · Mar 1, 2021Peer-reviewedGenomics

Multimodal cell type correspondence by intersectional mFISH in intact tissues

Philip R. Nicovich, Michael J. Taormina, Christopher A. Baker, Thuc Nghi Nguyen, Elliot R. Thomsen, Emma J. Garren, Brian Long, Melissa Gorham, Jeremy A. Miller, Travis A Hage, Alice Bosma-Moody, Gabe J. Murphy, Boaz P. Levi, Jennie Close, Bosiljka Tasic, , Hongkui Zeng

The paper presents a method combining spatial transcriptomics with optogenetic mapping to resolve cell type characteristics in mouse cortex.

bioRxiv · Jan 30, 2019 · PreprintNeuroscience

Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex

Stephanie C. Seeman, Luke Campagnola, Pasha A. Davoudian, Alex Hoggarth, Travis A Hage, Alice Bosma-Moody, Christopher A. Baker, Jung H. Lee, Ştefan Mihalaş, Corinne Teeter, Andrew Lin Ko, Jeffrey G. Ojemann, Ryder P. Gwinn, Daniel L. Silbergeld, Charles Cobbs, , Tim Jarsky

The paper examines sparse excitatory connectivity in adult mouse and human cortex using electrophysiology and optogenetics, finding sparse connections and synaptic dynamics across layers.

eLife · Sep 26, 2018Peer-reviewedNeuroscience

A suite of transgenic driver and reporter mouse lines with enhanced brain cell type targeting and functionality

Tanya L. Daigle, Linda Madisen, Travis A Hage, Matthew T. Valley, Ulf Knoblich, Rylan S. Larsen, Marc M. Takeno, Lawrence Huang, Hong Gu, Rachael Larsen, Maya Mills, Alice Bosma-Moody, La’Akea Siverts, Miranda Walker, Lucas T. Graybuck, , Hongkui Zeng

The paper introduces a new set of transgenic mouse lines for precise targeting and manipulation of brain cell types, enhancing genetic tools for neuroscience research.

Cell · Jan 1, 2018Peer-reviewedNeuroscience