Ross G. Lake

Deep Vein Thrombosis-primed neutrophils reshape the brain microenvironment to promote brain metastasis

This study shows that deep vein thrombosis primes neutrophils to promote brain metastasis in triple-negative breast cancer by enhancing their recruitment and NET formation.

Proteomic Profiling Identifies CLDN3 as a Tumor-Selective Therapeutic Target in Small Cell Lung Cancer

The paper identifies CLDN3 as a tumor-selective target in SCLC using proteogenomic analysis and validates its therapeutic potential with a monoclonal antibody.

Hepatobiliary Progenitor-like Reprogramming in Liver Metastases

This study identifies hepatobiliary progenitor-like reprogramming in liver metastases, driven by TGF-β and hypoxia, and shows its association with poor survival.

SCD1 inhibition synergizes with TMZ to improve IDH1 MUT glioma survival of mice via lipotoxic stress

This paper shows that inhibiting SCD1 with MF-438 enhances TMZ effectiveness in IDH1-mutant glioma mouse models by inducing lipotoxic stress and ferroptosis.

Cell type-centric interaction networks define spatial architecture of intrahepatic cholangiocarcinoma

This study defines the spatial architecture of intrahepatic cholangiocarcinoma using single-cell spatial proteomics and a graph-based deep learning framework to identify multicellular spatial patterns and their association with patient outcomes.

Co-Targeting Nuclear Export and Translation Initiation Uncovers a Therapeutic Vulnerability in Lethal Prostate Cancer

This study identifies co-inhibition of XPO1 and EIF4A1 as a therapeutic strategy for mCRPC, showing synergistic antitumor effects at reduced drug doses.

Low abundance of circulating tumor DNA in localized prostate cancer

The paper shows that ctDNA is undetectable in localized prostate cancer but present in metastatic cases, suggesting lower dissemination and detectability in early stages.