ImmunologyCell ReportsPeer-reviewed
SARS-CoV-2 ORF7a Drives Mitochondrial Dysfunction via PDK4 Activation and Complex I Inhibition
Raúl Fernández‐Rodríguez, Carmen M. Soto-Jiménez, Rebeca Acín‐Pérez…·Tránsito García‐García
This study shows that SARS-CoV-2 ORF7a causes mitochondrial dysfunction by activating PDK4 and inhibiting complex I, altering host metabolism.
DOI 10.1016/j.celrep.2026.117755