Blanca Dies López-Ayllón

This study identifies how a single mutation in the Omicron variant of SARS-CoV-2's ORF3a protein alters its host-cell remodelling effects, shifting from lipid accumulation to preserving Golgi structure.

This study shows that SARS-CoV-2 ORF7a causes mitochondrial dysfunction by activating PDK4 and inhibiting complex I, altering host metabolism.

This study shows that SARS-CoV-2 accessory proteins ORF3a and ORF9b suppress monocytic inflammatory responses, with Omicron variants enhancing this effect.

This study shows that SARS-CoV-2's ORF9b protein activates inflammasomes and caspase-1, and small molecules inhibiting its homodimerization reduce inflammation and restore interferon signaling.

The paper develops a cellular platform using SARS-CoV-2 ORF-expressing A549 cells to screen anti-inflammatory compounds from Fasciola hepatica, showing FhNEJ extract reduces IL11 levels.