Author

Luca Sigalotti

Centro di Riferimento OncologicoORCID 0000-0002-1436-2358Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Alessandro GronchiiD· 1 shared Alex KentsisiD· 1 shared Anna Maria FrezzaiD· 1 shared Cesare SoffientiniiD· 1 shared Elisa Savio· 1 shared Gian Paolo DagradaiD· 1 shared Loredana ClerisiD· 1 shared Marta BarisellaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alessandro GronchiORCID

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintAug 4, 2026

Histone deacetylase activity limits the response to EZH2 inhibition-based therapy in epithelioid sarcoma and is targetable by epigenetic combination

Noemi Arrighetti, Cesare Soffientini, Valentina Zuco…·Sandro Pasquali

This paper identifies HDAC inhibition as a strategy to overcome resistance to EZH2 inhibitors in INI1-deficient epithelioid sarcoma by restoring H3K27 acetylation and enhancing therapeutic response.

1 citation

humanChIP-seq

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