Histone deacetylase activity limits the response to EZH2 inhibition-based therapy in epithelioid sarcoma and is targetable by epigenetic combination
Noemi Arrighetti, Cesare Soffientini, Valentina Zuco, Stefano Percio, Loredana Cleris, Suzan Abdulrazak Ahmed, Elisa Savio, Luca Sigalotti, Roberta Maestro, Silvia Brich, Gian Paolo Dagrada, Marta Barisella, Paola Collini, Alex Kentsis, Paul H. Huang, , Sandro Pasquali
This paper identifies HDAC inhibition as a strategy to overcome resistance to EZH2 inhibitors in INI1-deficient epithelioid sarcoma by restoring H3K27 acetylation and enhancing therapeutic response.
bioRxiv · Aug 4, 2026 · PreprintCancer Biology