MicrobiologybioRxivPreprint
Mitochondrial cardiolipin sequestration of caspofungin underlies Cryptococcus neoformans inherent resistance and may contribute to cardiotoxicity
Anna Loksztejn, Rajendra Upadhya, Eduardo A. Caro…·Jennifer K. Lodge
This study shows caspofungin accumulates in Cryptococcus mitochondria via cardiolipin binding, reducing its effectiveness and linking to cardiotoxicity in human cells.