Mitochondrial cardiolipin sequestration of caspofungin underlies Cryptococcus neoformans inherent resistance and may contribute to cardiotoxicity
Anna Loksztejn, Rajendra Upadhya, Eduardo A. Caro, David M. Gooden, Adi Yona, Porter K. Ellis, Micha Fridman, Maria A. Schumacher, Richard G. Brennan, Maureen J. Donlin, Jennifer K. Lodge
This study shows caspofungin accumulates in Cryptococcus mitochondria via cardiolipin binding, reducing its effectiveness and linking to cardiotoxicity in human cells.
bioRxiv · Jan 20, 2026 · PreprintMicrobiology