Sadahiro Iwabuchi

This paper introduces Tol-mRNA, a modular mRNA platform that induces antigen-specific immune tolerance by delivering PD-L1 and TGF-β along with antigen, showing therapeutic benefits in murine models and human immune settings.

This study shows that hypomorphic Lig4 mutation in mice causes Th1-skewed intestinal inflammation under adaptive immunodeficiency.

This study characterizes peritoneal exudate cells in liver cirrhosis patients using single-cell and bulk RNA sequencing, revealing shifts in immune cell populations and gene expression with disease severity.

The paper introduces a method to align images from different imaging sessions by performing immunocytochemistry on the microscope stage and using biological structures as landmarks.

The paper shows that overexpressed torsinA proteins in astrocytes follow a mis-localization model, but endogenous torsinA is localized near the Golgi, suggesting caution in interpreting overexpression studies.

The paper localizes torsinA protein near the Golgi apparatus in cultured mouse neurons, contrasting previous overexpression studies.

The paper examines transcriptome profiles in mouse brain regions with a DYT1 dystonia mutation, finding subtle genotype-dependent changes across regions but not within individual regions.